Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University School of Medicine, Shanghai, China. Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.